Our research focuses on the role of epigenetics in human health and disease. DNA methylation is an epigenetic mark that must be properly established and maintained throughout development and the life of an organism. The growing number of human diseases that result when there is a disruption in this epigenetic information emphasizes its importance. In our lab, we utilize murine and non-human primate model systems to investigate the dynamics of DNA methylation (both 5-mC and 5-hmC) in neurodevelopmental health and disease states.
2015 Hartwell Investigator Reid Alisch, Ph.D., University of Wisconsin-Madison for “Blood-Based Diagnostic Test for Anxiety Disorder”
2017 National Research Service Awardee Andy Madrid, University of Wisconsin-Madison for “Defining the molecular origins of developmental brain disorders”
Listen to a recent description of our research that aired Nationally on Public Health Minute
Recent article from Spectrum news regarding our characterization of 5hmC in an autism mouse model.
Recent review: New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease, Madrid_et al reivew
6001 Research Park Blvd., Madison, WI 53719-1176